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Cytotoxicity of potential anti-tumour transition metal complexes
Author
Ho, Junming
Supervisor
Yan, Yaw Kai
Lee, Peter Peng Foo
Abstract
This thesis is concerned with the synthesis, physicochemical properties and cytotoxicity of salicylaldehyde semicarbazone ligands and their transition metal complexes.
A series of salicylaldehyde semicarbazone derivatives have been prepared and these were used as ligands for the preparation of their rhenium(I) carbonyl complexes. All the synthesized ligands and complexes were characterized by IR and NMR spectroscopy and elemental analyses. The crystal structure of the rhenium(I) complex of the N,N-dibutyl derivative reveals that the ligand acts as a bidentate ligand where it binds to the metal ion at the equatorial positions via the carbonyl oxygen and imine nitrogen donor atoms.
The synthesized compounds were screened for their cytotoxicity on the human leukemia (MOLT-4) cell line via the colorimetric MTT assay and results are expressed in terms of IC50 values. Subtle changes in the terminal amide substituents can lead to drastic differences in cytotoxic activity of the ligands and the cytotoxicity of the rhenium(I) complexes was greater than the ligands.
A series of salicylaldehyde semicarbazone derivatives have been prepared and these were used as ligands for the preparation of their rhenium(I) carbonyl complexes. All the synthesized ligands and complexes were characterized by IR and NMR spectroscopy and elemental analyses. The crystal structure of the rhenium(I) complex of the N,N-dibutyl derivative reveals that the ligand acts as a bidentate ligand where it binds to the metal ion at the equatorial positions via the carbonyl oxygen and imine nitrogen donor atoms.
The synthesized compounds were screened for their cytotoxicity on the human leukemia (MOLT-4) cell line via the colorimetric MTT assay and results are expressed in terms of IC50 values. Subtle changes in the terminal amide substituents can lead to drastic differences in cytotoxic activity of the ligands and the cytotoxicity of the rhenium(I) complexes was greater than the ligands.
Date Issued
2007
Call Number
QD411.8.T73 Ho
Date Submitted
2007