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Synthesis, G-quadruplex binding and cytotoxicity of copper (II) complexes
Citation
Koh, K. J. T. (2020). Synthesis, G-quadruplex binding and cytotoxicity of copper (II) complexes [Doctoral dissertation, National Institute of Education, Nanyang Technological University, Singapore]. https://doi.org/10.32658/10497/22621
Author
Koh, Kelvin Jin Tai
Supervisor
Yan, Yaw Kai
Lee, Peter Peng Foo
Abstract
In this thesis, four major investigations involving 20 new ligands (semicarbazone and 1,2,4-triazole derivatives) and 28 new copper(II) complexes based on these ligands were carried out. The copper(II) complexes and some ligands were studied for their Gquadruplex DNA binding affinities, cancer cell cytotoxicity and stability in various biologically-relevant solutions.
Date Issued
2020
Call Number
QD474 Koh
Date Submitted
2020