Please use this identifier to cite or link to this item: http://hdl.handle.net/10497/15527
Title: 
Quorum quenching revisited: From signal decays to signalling confusion
Authors: 
Keywords: 
Acylase
Anti-infective
Anti-biofouling
Aquaculture
Lactonase
N-acylhomoserine lactone
Paraoxonase
Oxidoreductase
Quorum sensing
Quorum quenching resistance
Signalling confusion
Issue Date: 
2012
Citation: 
Hong, K. W., Koh, C. L., Sam, C. K., Yin, W. F., & Chan, K. G. (2012). Quorum quenching revisited: From signal decays to signalling confusion. Sensors, 12(4), 4661-4696.
Abstract: 
In a polymicrobial community, while some bacteria are communicating with neighboring cells (quorum sensing), others are interrupting the communication (quorum
quenching), thus creating a constant arms race between intercellular communication. In the past decade, numerous quorum quenching enzymes have been found and initially thought
to inactivate the signalling molecules. Though this is widely accepted, the actual roles of these quorum quenching enzymes are now being uncovered. Recent evidence extends the role of quorum quenching to detoxification or metabolism of signalling molecules as food and energy source; this includes “signalling confusion”, a term coined in this paper to refer to the phenomenon of non-destructive modification of signalling molecules. While quorum quenching has been explored as a novel anti-infective therapy targeting, quorum sensing
evidence begins to show the development of resistance against quorum quenching.
URI: 
ISSN: 
1424-8220
Other Identifiers: 
10.3390/s120404661
Website: 
Appears in Collections:Journal Articles

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