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Plant-derived natural products as sources of anti-quorum sensing compounds
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Koh, C. L., Sam, C. K., Yin, W. F., Tan, L. Y., Krishnan, T., Chong, Y. M., & Chan, K. G. (2013). Plant-derived natural products as sources of anti-quorum sensing compounds. Sensors, 13(5), 6217-6228.
Quorum sensing is a system of stimuli and responses in relation to bacterial cell
population density that regulates gene expression, including virulence determinants.
Consequently, quorum sensing has been an attractive target for the development of novel anti-infective measures that do not rely on the use of antibiotics. Anti-quorum sensing has been a promising strategy to combat bacterial infections as it is unlikely to develop multidrug resistant pathogens since it does not impose any selection pressure. A number of anti-quorum sensing approaches have been documented and plant-based natural products
have been extensively studied in this context. Plant matter is one of the major sources of chemicals in use today in various industries, ranging from the pharmaceutical, cosmetic,and food biotechnology to the extile industries. Just like animals and humans, plants are onstantly exposed to bacterial infections, it is therefore ogical to expect that plants have eveloped sophisticated of chemical mechanisms to combat pathogens. In this review, we
have surveyed the various types of plant-based natural products that exhibit anti-quorum sensing properties and their anti-quorum sensing mechanisms.
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