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Serum lipids, serum insulin, plasma fibrinogen and aerobic capacity in obese and non-obese Singaporean boys
Stensel, D., Lin, F. P., Ho, T. F., & Aw, T. C. (2001). Serum lipids, serum insulin, plasma fibrinogen and aerobic capacity in obese and non-obese Singaporean boys. International Journal of Obesity, 25(7), 984-989.
OBJECTIVES: To compare blood lipids, lipoproteins, apoproteins, fibrinogen, insulin and aerobic capacity in obese and non-obese Chinese Singaporean boys. To examine relationships between blood metabolites, body composition and aerobic 5 capacity in these groups.
SUBJECTS: Forty Chinese Singaporean boys aged 13 to 15 years. Classified as 10 obese (N=20) or non-obese (N=20) based on adiposity (fat mass/fat free mass): >0.60 = obese, <0.40 = non-obese.
MEASUREMENTS: Body composition (dual energy X-ray absorptiometry), waist circumference, peak oxygen consumption (VO2 peak), serum concentrations of total 15 cholesterol, triacylglycerol, high density lipoprotein cholesterol (HDL-C), total cholesterol/HDL-C, apoproteins AI and B, lipoprotein(a), insulin and glucose. Plasma concentration of fibrinogen.
RESULTS: Obese boys had significantly (P<0.01) higher (mean ± SD) 20 concentrations of serum triacylglycerol (1.51 ± 0.65 v 1.04 ± 0.34 mmol/l), serum insulin (24.1 ± 11.5 v 12.3 ± 4.45 mU/l) and plasma fibrinogen (4.01 ± 0.54 v 3.35 ± 0.76 g/l) than non-obese boys. Within the non-obese group plasma fibrinogen concentration was significantly related to percentage body fat (r=0.546, P<0.05). VO2 peak relative to body mass (ml/kg/min or ml/kg-0.67/min) was significantly (P<0.001) lower in obese compared to non-obese boys but absolute VO2 peak (l/min), adjusted for fat free mass via analysis of covariance, was higher in obese than non-obese boys (P<0.01). Partial correlations revealed that 5 none of the blood metabolites were significantly related to VO2 peak independent of body fatness.
CONCLUSIONS: Obesity was related to elevated concentrations of serum triacylglycerol, serum insulin and plasma fibrinogen in Chinese Singaporean boys. These elevated concentrations did not appear to be associated with a lower aerobic capacity (independent of body fatness) in the obese.
This is the final draft, after peer-review, of a manuscript published in the International Journal of Obesity. The published version is available online at http://dx.doi.org/10.1038/sj.ijo.0801667
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