Please use this identifier to cite or link to this item: http://hdl.handle.net/10497/21266
Title: 
Authors: 
Supervisor: 
Yan, Yaw Kai
Issue Date: 
2019
Abstract: 
This dissertation describes the synthesis and cytotoxicity studies of a series of substituted salicylaldehyde 5-carboxy-2-pyridyl hydrazones [R(OH)C6H3CH=NNHC5H3N(CO2H); R=H, Br, Cl, OH, OMe, NO2], and their bromotricarbonylrhenium(I) complexes.

The compounds were characterised by proton nuclear magnetic resonance (NMR) spectroscopy, elemental analysis and solid-state infrared (IR) spectroscopy.

The cytotoxicity of these synthesized compounds against the MOLT-4 human leukaemia cell line was determined by the colorimetric MTT assay. Cytotoxicity of the ligands varied with changes made to the substituent on the 5th position of the benzene ring with the bromo-substituted ligand being the most cytotoxic (IC50 = 11 μM). The rhenium(I) complexes are less cytotoxic(IC50 > 104 μM) than the ligands (11 – 58 μM).
URI: 
Call Number: 
QD412.R4 Won
File Permission: 
Restricted
File Availability: 
With file
Appears in Collections:Master of Science (Life Sciences)

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