Please use this identifier to cite or link to this item: http://hdl.handle.net/10497/22214
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dc.contributor.authorCruickshank, Travisen
dc.contributor.authorBartlett, Danielleen
dc.contributor.authorGovus, Andrewen
dc.contributor.authorHannan, Anthonyen
dc.contributor.authorTeo, Wei-Pengen
dc.contributor.authorMason, Sarahen
dc.contributor.authorLo, Johnnyen
dc.contributor.authorZiman, Melen
dc.date.accessioned2020-08-13T03:19:16Z-
dc.date.available2020-08-13T03:19:16Z-
dc.date.issued2020-
dc.identifier.citationCruickshank, T., Bartlett, D., Govus, A., Hannan, A., Teo, W. P., Mason, S., Lo, J., & Ziman, M. (2020). The relationship between lifestyle and serum neurofilament light protein in Huntington’s disease. Brain and Behavior, 10(5), Article e01578. https://doi.org/10.1002/brb3.1578en
dc.identifier.issn2162-3279 (print)-
dc.identifier.issn2157-9032 (online)-
dc.identifier.urihttp://hdl.handle.net/10497/22214-
dc.description.abstractObjectives Serum neurofilament light protein (NfL) is a promising marker of disease onset and progression in Huntington's disease (HD). This study investigated associations between lifestyle factors and NfL levels in HD mutation carriers compared to healthy age‐ and sex‐matched controls. Materials and Methods Participants included 29 HD mutation carriers and 15 healthy controls. Associations between serum NfL concentrations and lifestyle factors, including cardiorespiratory fitness, social network size and diversity, physical activity, cognitive reserve, smoking status, and alcohol consumption, were examined using a stepwise multivariable linear regression model. Results Higher NfL levels were associated with lower cognitive reserve, social network size and diversity and cardiorespiratory fitness in HD mutation carriers. Group × lifestyle factor effects were observed between lower serum NfL levels and a greater social network diversity. Conclusion These findings highlight a relationship between lifestyle factors and NfL levels in HD mutations carriers; however, longitudinal studies are required to confirm if these observed relationships persist over time.en
dc.language.isoenen
dc.subjectCardiorespiratory fitnessen
dc.subjectCognitive reserveen
dc.subjectLifestyleen
dc.subjectNeurofilament light proteinen
dc.subjectSocial networken
dc.titleThe relationship between lifestyle and serum neurofilament light protein in Huntington’s diseaseen
dc.typeArticleen
dc.identifier.doi10.1002/brb3.1578-
dc.grant.idLottery west (Grant no. #107/20090827)-
dc.grant.idNHMRC Principal Research Fellowship (Grant no. #1117148)-
local.message.claim2021-12-27T11:06:08.987+0800|||rp00019|||submit_approve|||dc_contributor_author|||None*
item.openairetypeArticle-
item.fulltextWith file-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
item.grantfulltextOpen-
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