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Copper catalyzed N-arylation of sulfonamides with aryl bromides under ligand-free conditions

2023, Teo, Yong Chua, Tan, Yun-Ru, M. Kyra Saanvi, Loh, Chu Ken, Tan, Swee Ngin

A practical strategy for the C-N cross-coupling of both aliphatic and aromatic sulfonamides with a variety of substituted aryl bromides is reported. Under the optimized conditions, a good representative of N-arylated products were obtained in good to excellent yields (up to 78 %) under the ligand-free conditions.