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Synthesis and biological evaluation of rhenium(i) complexes of salicylaldehyde 5-carboxy-2-pyridyl hydrazones
Author
Wong, Caviner Hai Ling
Supervisor
Yan, Yaw Kai
Abstract
This dissertation describes the synthesis and cytotoxicity studies of a series of substituted salicylaldehyde 5-carboxy-2-pyridyl hydrazones [R(OH)C6H3CH=NNHC5H3N(CO2H); R=H, Br, Cl, OH, OMe, NO2], and their bromotricarbonylrhenium(I) complexes.
The compounds were characterised by proton nuclear magnetic resonance (NMR) spectroscopy, elemental analysis and solid-state infrared (IR) spectroscopy.
The cytotoxicity of these synthesized compounds against the MOLT-4 human leukaemia cell line was determined by the colorimetric MTT assay. Cytotoxicity of the ligands varied with changes made to the substituent on the 5th position of the benzene ring with the bromo-substituted ligand being the most cytotoxic (IC50 = 11 μM). The rhenium(I) complexes are less cytotoxic(IC50 > 104 μM) than the ligands (11 – 58 μM).
The compounds were characterised by proton nuclear magnetic resonance (NMR) spectroscopy, elemental analysis and solid-state infrared (IR) spectroscopy.
The cytotoxicity of these synthesized compounds against the MOLT-4 human leukaemia cell line was determined by the colorimetric MTT assay. Cytotoxicity of the ligands varied with changes made to the substituent on the 5th position of the benzene ring with the bromo-substituted ligand being the most cytotoxic (IC50 = 11 μM). The rhenium(I) complexes are less cytotoxic(IC50 > 104 μM) than the ligands (11 – 58 μM).
Date Issued
2019
Call Number
QD412.R4 Won