Options
C-reactive protein and functional capacity of obese and normal male adolescents in Singapore
Author
Chng, Doreen Yen Peng
Supervisor
Wong, Patricia
Abstract
Obesity is a risk factor for the development of many modem day lifestyle diseases including atherosclerosis. C-Reactive Protein (CRP) is an acute phase protein produced mainly by hepatocytes arid is usually present during inflammations. Recent studies suggested that obesity, an inflammatory disorder is associated with elevated levels of CRP which could be involved in the pathogenesis of atherosclerosis. Limited studies done in western countries suggested an association between CRF levels and functional capacity, also termed as physical fitness levels. However, these studies employed non-laboratory measure of functional capacity. To date. not much data are available regarding the relationship between CRP levels and functional capacity of Asian male adolescents. This study involved 14 normal (BMIi25) and 16 obese (BMI>30) male adolescents, of Asian descent aged between 14- 18 years. Fasting serum CRF' and blood lipids profile (Total cholesterol, High Density Lipoprotein-Cholesterol (HDL), Low Density Lipoprotein-Cholesterol (LDL) and Tnglyceride) were determined. Sub-maximal cardiovascular fitness (Predicted Work Capacity at heart rate 170bpm. PWC170) and body composition assessments (Skinfold measurements and Dual Energy X-Ray absorptiometry, DEXA) were also determined. Statistically significant differences in CRP levels, lipid profiles and functional capacity between obese and normal lcan adolescents were observed. Obese adolescents exhibited higher levels of CRF, despite normal levels of LDL, as compared to normal lean adolescents, which may suggest a higher risk of developing cardiovascular disease. There is a significant inverse correlation( r = -0.45 1, p<0.05) between CRP levels and functional capacity. The significant inverse correlation (r = -0.601, p<0.05) between CRP levels and functional capacity in only obese individuals was also observed. In the context of this study, it is suggested that improved functional capacity levels may be a useful therapeutic option in lowering CRP levels, hence reducing the risk of developing cardiovascular diseases.
Date Issued
2005
Call Number
RJ399.C6 Chn
Date Submitted
2005