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Trikoramide A, a prenylated cyanobactin from the marine cyanobacterium symploca hydnoides
Citation
Phyo, M. Y., Ding, C. Y. G., Goh, H. C., Goh, J. X., Ong, J. F. M., Chan, S. H., Yung, P. Y. M., Candra, H., & Tan, L. T. (2019). Trikoramide A, a prenylated cyanobactin from the marine cyanobacterium symploca hydnoides. Journal of Natural Products, 82(12), 3482-3488. https://doi.org/10.1021/acs.jnatprod.9b00675
Author
Phyo, Ma Yadanar
•
Ding, Gary Chi Ying
•
Goh, Hui Chin
•
Goh, Jun Xian
•
Ong, Ji Fa Marshall
•
Chan, Siew Herng
•
Yung, Pui Yi Maria
•
Candra, Hartono
•
Abstract
A new cyclic decapeptide, trikoramide A (1), has been isolated from samples of the marine cyanobacterium Symploca hydnoides, collected from Bintan Island, Indonesia. Trikoramide A (1) is a C-prenylated cyclotryptophan-containing cyanobactin. Its planar structure was deduced by 1D and 2D NMR spectroscopy as well as HR–MS/MS data. In addition, its absolute configuration was determined by Marfey’s method and 2D NOESY NMR spectroscopic analysis. Compound 1 possessed cytotoxicity against the MOLT-4 and AML2 cancer cell lines with IC50 values of 4.8 and 8.2 μM, respectively.
Date Issued
2019
Publisher
American Chemical Society
Journal
Journal of Natural Products