Please use this identifier to cite or link to this item: http://hdl.handle.net/10497/22407
Title: 
Authors: 
Keywords: 
Doped nanocrystals
Zinc sulfide
Mn dopant
Ligand chemistry
Cancer nanotheranostics
Issue Date: 
2020
Citation: 
Ang, E. H., Zeng, J., Gomathy Sandhya Subramanian, Vijila Chellappan, Thankiah Sudhaharan, Parasuraman Padmanabhan, Gulyás, B., & Subramanian Tamil Selvan. (2020). Silica-coated Mn-doped ZnS nanocrystals for cancer theranostics. ACS Applied Nano Materials, 3(3), 3088-3096. https://doi.org/10.1021/acsanm.0c00598
Abstract: 
Doped nanocrystals such as manganese-doped zinc sulfide (ZnS:Mn) are useful nanomedicine probes for cancer cell labeling and anticancer drug delivery. However, the synthesis and retention of fluorescence of these nanocrystals is highly indispensable for efficient cell theranostics. Herein, we report a modified synthesis of highly fluorescent hydrophobic ZnS:Mn nanocrystals with the advent of dual ligands. Our results demonstrate that the alkylamine ligand with the carbon chain length of C18 promotes the diffusion of Mn from the surface into the interior of ZnS nanocrystals. Optical measurements show that the quantum yield of Mn (QYMn) can reach as high as 80% in the presence of a dual ligand combination of oleylamine–octadecylamine because of the increased probability of 4T16A1 emission, originating from the energy transfer of ligated nanocrystals. These doped nanocrystals after ligand exchange of organic ligands with glutathione exhibited a high retention of quantum yield (QY: ∼50–60%), and further coating with silica showed the QY of ∼35–40%. Finally, we show the application of these doped nanocrystals for cancer theranostics such as HeLa cell labeling and anti-cancer drug delivery.
Description: 
This is the final draft, after peer-review, of a manuscript published in ACS Applied Nano Materials. The published version is available online at https://doi.org/10.1021/acsanm.0c00598
URI: 
ISSN: 
2574-0970
Other Identifiers: 
10.1021/acsanm.0c00598
Website: 
Grant ID: 
JCOAG03-FG03
Funding Agency: 
Joint Council Office, A*STAR, Singapore
Appears in Collections:Journal Articles

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