Please use this identifier to cite or link to this item: http://hdl.handle.net/10497/23197
Title: 
Authors: 
Supervisor: 
Teo, Yong Chua
Issue Date: 
2021
Abstract: 
This study aims to fill in a gap in our collective knowledge regarding the use of Cu2O as a copper catalyst precursor for Ullmann-type cross-coupling reactions; in particular, for N-arylation of sulfonamides with aryl halides. Reported herein are the results of optimisation studies and substrate studies for both reactants. During the optimisation, it was found that polar aprotic solvents, bases having large cations with a dispersed charge, and copper salts, all contributed to the high yields of the reaction. Subsequently, factors affecting the reaction, such as the electronic and steric environments, were investigated using a selection of substituted aryl halides. In general, it was found that reaction with electron-withdrawing groups on the aryl halide were controlled by steric factors, while reaction with electron-donating groups on the aryl halide were more controlled by electronic factors. Finally, a reaction mechanism via π-complexation with the Cu catalyst is proposed.
URI: 
Issued Date: 
2021
Call Number: 
QD181.C9 Low
File Permission: 
Restricted
File Availability: 
With file
Appears in Collections:Master of Science (Life Sciences)

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