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Iron-catalyzed benzylic addition of 2-methyl azaarenes to substituted trifluoromethyl ketones
Citation
Lim, J. A., & Teo, Y.-C. (2021). Iron-catalyzed benzylic addition of 2-methyl azaarenes to substituted trifluoromethyl ketones. Synthetic Communications, 51(7), 1076-1084. https://doi.org/10.1080/00397911.2020.1867178
Abstract
This paper demonstrated a new and economical methodology using Fe(ClO4)2·H2O as a catalyst for the direct C(sp3)–H functionalization of 2-methyl azaarenes via addition to trifluoromethyl ketones. The use of Fe salts as a Lewis acid catalyst has shown great potential as an accessible, affordable, and effective catalyst for the reaction. Under mild, optimized conditions, an extensive range of 2-alkenylated azaarenes was produced with yields of up to 95%.
Date Issued
2021
Publisher
Taylor & Francis
Journal
Synthetic Communications
Project
RI 5/17 TYC
Grant ID
NIE Academic Research Fund
Funding Agency
National Institute of Education, Singapore