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Title: An analysis of blinding success in a randomised controlled trial of fish oil omega-3 fatty acids
Authors: Liu, Jean C. J.
Raine, Adrian
Ang, Rebecca Pei-Hui
Fung, Daniel S. S.
Keywords: ADHD
Clinical trials
Issue Date: 2015
Citation: Liu, J. C. J., Raine, A., Ang, R. P. H., & Fung, D. S. S. (2015). An analysis of blinding success in a randomised controlled trial of fish oil omega-3 fatty acids. Annals Academy of Medicine, 44(3), 85-91.
Abstract: Introduction: Incidental reports collected in clinical trials suggest that amongst participants,
omega-3 fatty acids derived from fi sh oil (‘omega-3’) may be diffi cult to blind. Materials and
Methods: We conducted a systematic evaluation of blinding success in a 24-week trial of
omega-3 versus an oil-based placebo. Within 1 week of supplement commencement (Week
1), a blinding questionnaire was completed by 131 children enrolled in a trial of omega-3
for the treatment of disruptive behaviour disorders. A version of the questionnaire was
also completed by their parents at Week 1, and by the children at the end of supplement
administration (Week 24). Results: Participants were unable to differentiate omega-3
from placebo, and accuracy did not improve as a function of: the confi dence of guesses,
reason for guesses, notice of any change, beliefs about what should change, or time. Child
and parent guesses also showed high concordance. Conclusion: Taken together, these data
provide strong evidence that the identity of omega-3 can be blinded to participants.
ISSN: 0304-4602
Appears in Collections:Journal Articles

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