Please use this identifier to cite or link to this item: http://hdl.handle.net/10497/22214
Title: 
Authors: 
Subjects: 
Cardiorespiratory fitness
Cognitive reserve
Lifestyle
Neurofilament light protein
Social network
Issue Date: 
2020
Citation: 
Cruickshank, T., Bartlett, D., Govus, A., Hannan, A., Teo, W. P., Mason, S., Lo, J., & Ziman, M. (2020). The relationship between lifestyle and serum neurofilament light protein in Huntington’s disease. Brain and Behavior, 10(5), Article e01578. https://doi.org/10.1002/brb3.1578
Abstract: 
Objectives
Serum neurofilament light protein (NfL) is a promising marker of disease onset and progression in Huntington's disease (HD). This study investigated associations between lifestyle factors and NfL levels in HD mutation carriers compared to healthy age‐ and sex‐matched controls.

Materials and Methods
Participants included 29 HD mutation carriers and 15 healthy controls. Associations between serum NfL concentrations and lifestyle factors, including cardiorespiratory fitness, social network size and diversity, physical activity, cognitive reserve, smoking status, and alcohol consumption, were examined using a stepwise multivariable linear regression model.

Results
Higher NfL levels were associated with lower cognitive reserve, social network size and diversity and cardiorespiratory fitness in HD mutation carriers. Group × lifestyle factor effects were observed between lower serum NfL levels and a greater social network diversity.

Conclusion
These findings highlight a relationship between lifestyle factors and NfL levels in HD mutations carriers; however, longitudinal studies are required to confirm if these observed relationships persist over time.
URI: 
ISSN: 
2162-3279 (print)
2157-9032 (online)
DOI: 
Grant ID: 
Lottery west (Grant no. #107/20090827)
NHMRC Principal Research Fellowship (Grant no. #1117148)
File Permission: 
Open
File Availability: 
With file
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