Options
Chemical constituents of the marine cyanobacterium, Lyngbya majuscula
Author
Ng, Joyce Poh Chuan
Supervisor
Tan, Lik Tong
Abstract
Natural products from marine sources have a wealth of interesting and highly complex chemistry and they have been of great interest in recent years. Researchers travel around the world obtaining samples to analyze and evaluate in drug discovery screens or bioassays. The aim of this research is to explore new bioactive compounds from the marine cyanobacterium, Lyngbya majuscula, collected from Pulau Hantu Besar, Singapore. An organic extract was obtained from the cyanobacterial sample through extraction and the extract was subjected to bioassay-guided fractionation using Vacuum Liquid Chromatography (VLC) and High Performance Liquid Chromatography (HPLC) to purify the new molecule designated as 120-5. Although the compound 120-5 did not show bioactivity in the brine shrimp lethality test, it was nevertheless reported as a new molecule. Various one and two-dimensional NMR experiments as well as mass spectrometry had been used in elucidating the chemical structure of the compound. Based on the chemical structure of 120-5, a proposed biosynthesis process for the compound was also presented. This molecule is proposed to be biosynthesized by a combination of polyketide/fatty acid synthase and nonribosomal polypeptide synthetase enzymatic system.
Date Issued
2009
Call Number
RS160.7 Ng
Date Submitted
2009