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Rifkin-Graboi, Anne
- PublicationMetadata onlyNutrient trajectories during infancy and their associations with childhood neurodevelopment(Springer, 2023)
; Chong, Mary F. F.Purpose To examine the associations between infants’ dietary nutrient trajectories and subsequent neurodevelopment during childhood in the Growing Up in Singapore Towards healthy Outcomes study. Methods One-day food records were collected at ages 6, 9 and 12 months, whilst Bayley Scales of Infant and Toddler Development-III and Kaufman Brief Intelligence Test-2 were conducted at ages 24 and 54 months respectively. Nutrient trajectories were constructed using multi-level mixed modelling and associations with neurodevelopment (24 months: n = 484; 54 months: n = 444) were examined using adjusted multivariable linear regression. Results At age 24 months, higher protein intake (at 6 months) and increasing rate of intake (from 6 to 12 months) were associated with higher fine motor score [β = 0.17 SD (95% CI 0.03, 0.31) and 0.62 SD (0.10, 1.14) respectively]. Higher fat intake was associated with higher receptive language score [0.04 SD (0.003, 0.07)], but increasing rate of intake was associated with lower expressive language [− 0.20 SD (− 0.39, − 0.01)] and fine motor [− 0.29 SD (− 0.48, − 0.10)] scores. Higher carbohydrate intake was associated with lower gross motor score [− 0.07 SD (− 0.14, − 0.005)], but increasing rate of intake was associated with higher receptive language [0.44 SD (0.08, 0.81)] and fine motor [0.56 SD (0.18, 0.93)] scores. Increasing rate of dietary fibre intake was associated with higher fine motor scores [0.63 SD (0.16, 1.10)]. No significant associations were observed with neurodevelopment at 54 months. Conclusion Our findings provide greater understanding of how nutrition over time could have varying effects on child neurodevelopment.36 - PublicationOpen AccessPhysical discipline as a normative childhood experience in Singapore(Springer, 2023)
; Scopus© Citations 4 54 334 - PublicationMetadata onlyAssociations between infant screen use, electroencephalography markers, and cognitive outcomes(American Medical Association, 2023)
; WOS© Citations 10Scopus© Citations 23 127 - PublicationMetadata onlyThe importance of positive environments on infant and early childhood neurodevelopment: A review and preview of upcoming, "BE POSITIVE," researchWhy do our brains change so much in early life? Why do they continue to develop over time? What are the implications of prolonged neural plasticity for interventions, learning, and childhood well-being? Humans live among ever-changing circumstances and therefore require extensive neurocircuitry supporting abilities to learn, regulate, and respond to information throughout life. Nevertheless, biological plasticity is energetically costly, and so it may be advantageous for infants to take a “best guess” at the type of environment in which they will likely be raised. Will it be dangerous? Will it be filled with unpredictability and a lack of control? Or, will it be comprised of support, certainty, and access to resources? These are important questions: different skills are necessary to succeed in different types of environments. In this chapter, we will consider how brain development unfolds, especially in early life. We will ask, why, from a biological standpoint, early experience impacts developmental trajectories. Next, we will specifically consider effects of the caregiving environment upon neurodevelopment and related implications for individual differences at school age. Gaps in the knowledge base, especially with regard to how such relationships unfold outside of low-risk North American and European homes and school systems, will be highlighted. The reader will learn about a new collaborative Singaporean study, “BE POSITIVE,” that aims to address these gaps starting in children 4 months to 4 years. Finally, we will consider ways such research can be applied to shaping interventions and policies aimed at increasing educational success and well-being.
155 - PublicationMetadata onlyIntroduction to early childhood development and research in SingaporeEducation and well-being care are important throughout life, but especially so during early childhood, a time characterized by profound neural change. Importantly, early life experiences and neurodevelopment, in turn, lay the foundation for the subsequent ways in which neurodevelopment unfolds. As neurodevelopment is influenced by both genetic and environmental factors, it is not surprising that the quality of early childhood experiences has been found to have short- and long-term impacts upon individuals and society. For example, early environments characterized by relative responsiveness from caregivers (Fraley et al., 2013; Raby et al., 2015) may lead to academic and/or social competence even into adulthood. On the other hand, early childhood experiences with poverty and/or low socioeconomic status, exposure to parental mental health difficulties, forms of insecure attachment, and abuse or trauma have been linked to outcomes such as lower levels of school readiness, attentional problems, and/or difficulties in socioemotional development (e.g., Psychogiou et al., 2020; Fearon & Belsky, 2004; Dearing et al., 2001; Enlow et al., 2012).
374 - PublicationOpen AccessVariation in maternal sensitivity and the development of memory biases in preschoolers.(Frontiers, 2023)
; Introduction: Links between maternal sensitivity, hippocampal development, and memory abilities suggests early life insensitive care may shape structures and schemas influencing future decisions and stress management, biasing children to negative information. While it is possible that this pattern of neurodevelopment may have adaptive consequences, for example, preventing children from encountering untoward experience with future adversity, it may also leave some children at risk for the development of internalizing problems.
Methods: Here, in a Two Wave Study, we examine whether insensitive care predicts sub sequentially assessed memory biases for threatening (but not happy) stimuli in preschoolers (n = 49), and if such relations cut across different forms of relational memory, i.e., memory for relations between two “items,” between an “item” and its spatial location, and an “item” and its temporal sequence. In a subset (n = 18) we also examine links between caregiving, memory, and hippocampal subregion volume.
Results: Results indicate no main or interactive influence of gender on relational memory. However, insensitive caregiving predicted the difference between Angry and Happy memory during the Item-Space condition (B = 2.451, se = 0.969, p = 0.014, 95% CI (0.572, 4.340)], as well as memory for Angry (but not Happy) items [B = −2.203, se = 0.551, p < 0.001, 95% CI (−3.264,−1.094)]. Memory for the difference between Angry and Happy stimuli in the Space condition associated with larger right hippocampal body volumes (Rho = 0.639, p = 0.004). No relations were observed with internalizing problems.
Discussion: Results are discussed with reference to developmental stage and in consideration of whether negative biases may serve as an intermediate factor linking early life insensitive care and later socioemotional problems including an increased incidence of internalizing disorders.
WOS© Citations 1Scopus© Citations 2 98 173 - PublicationMetadata onlyMaternal distress and parenting during COVID-19: Differential effects related to pre-pandemic distress?(BioMed Central, 2023)
WOS© Citations 1Scopus© Citations 2 38 - PublicationMetadata onlyNeonatal nucleus accumbens microstructure modulates individual susceptibility to preconception maternal stress in relation to externalizing behaviors(Elsevier, 2024)
; Objective
Maternal stress influences in utero brain development and is a modifiable risk factor for offspring psychopathologies. Reward circuitry dysfunction underlies various internalizing and externalizing psychopathologies. This study examined (1) the association between maternal stress and microstructural characteristics of the neonatal nucleus accumbens (NAcc), a major node of the reward circuitry, and (2) whether neonatal NAcc microstructure modulates individual susceptibility to maternal stress in relation to childhood behavioral problems.
Method
K-means longitudinal cluster analysis was performed to determine trajectories of maternal stress measures (Perceived Stress Scale [PSS], hair cortisol) from preconception to the third trimester. Neonatal NAcc microstructural measures (orientation density index [ODI] and intracellular volume fraction [ICVF]) were compared across trajectories. We then examined the interaction between maternal stress and neonatal NAcc microstructure on child internalizing and externalizing behaviors, assessed between ages 3 and 4 years.
Results
Two trajectories of maternal stress magnitude (“low”/“high”) were identified for both PSS (n = 287) and hair cortisol (n = 336). Right neonatal NAcc ODI (rNAcc-ODI) was significantly lower in “low” relative to “high” PSS trajectories (n = 77, p = .04). PSS at preconception had the strongest association with rNAcc-ODI (r = 0.293, p = .029). No differences in NAcc microstructure were found between hair cortisol trajectories. A significant interaction between preconception PSS and rNAcc-ODI on externalizing behavior was observed (n = 47, p = .047).
Conclusion
Our study showed that the preconception period contributes to in utero NAcc development, and that NAcc microstructure modulates individual susceptibility to preconception maternal stress in relation to externalizing problems.97 - PublicationMetadata onlyDomain specificity of mastery-motivation-related behaviours in relation to Singaporean preschoolers’ mathematical performance(Springer, 2024)
; 70 - PublicationOpen AccessLocal evidence synthesis on early childhood education(Office of Education Research, National Institute of Education, Singapore, 2021)
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